Protein Purification and Isolation Market Size & Share Analysis - Growth Trends & Forecasts (2023 - 2028)

The Protein Purification and Isolation Market is segmented by Product (Instruments and Consumables), by Technology (Precipitation, Ultrafiltration, Chromatography, Electrophoresis, and Western Blotting), by End User (Academic and Research Institutes, Pharmaceutical and Biotechnological Companies, Contract Research Organizations (CROs), and Hospitals) and Geography (North America, Europe, Asia-Pacific, Middle East, and Africa, and South America). The report offers the value (in USD million) for the above segments.

Protein Purification & Isolation Market Size

Protein Purification and Isolation Market Size
Study Period 2018 - 2028
Base Year For Estimation 2021
CAGR 10.90 %
Fastest Growing Market Asia-Pacific
Largest Market North America
Market Concentration High

Major Players

Protein Purification and Isolation Market Major Players

*Disclaimer: Major Players sorted in no particular order

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Protein Purification & Isolation Market Analysis

The protein purification and isolation market are expected to register a CAGR of 10.9% over the forecast period (2022-2027).

The main challenge for the healthcare industry in many countries was to limit the spread of COVID-19 among people and provide the best care to infected patients and decrease the number of possible deaths. A profound impact on the protein purification and isolation market was observed as well.

The disruption in the supply chain during COVID-19 and delay in delivery of essential products required for the manufacturing of the protein purification and isolation kits reagents and consumables imposed an adverse effect on the protein purification and isolation market. Some major issues faced by the market during a pandemic include trucking bottlenecks and port checkpoints slowing down their deliveries including critical supplies, export bans imposed in many countries, only a few manufacturing units functional, and a lack of healthcare workers to transport and produce products. Therefore, such a scenario hindered the market growth initially. However, in later times the demand for protein purification and isolation procedures increased as it is used for the analysis and researh work related to evere acute respiratory syndrome coronavirus (SARS-CoV-2). For instance, according to the study titled, " Recombinant Protein Expression and Purification of N, S1, and RBD of SARS-CoV-2 from Mammalian Cells and Their Potential Applications" published by National Library of Medicine in September 2021, there is a strong demand for diagnostic and serological supplies across the global, as it is necessary for countries to establish their own technologies for the production of high-quality biomolecules. The two main viral antigens used for diagnosis of SARS-CoV-2 are the structural proteins spike (S) protein and nucleocapsid (N) protein. Since, protein purification and isolation is one of the initial and essential step needs to be followed in order to proceed with furthur diagnosis and reasearch work, therefore, such facts indicates that the market has witnessed considerable growth during the pandemic.

Increasing in investment in pharmaceutical and biotechnological research and development and rising need for more accurate and rapid purification kits are some of the major factors driving the market growth. For instance, as per the report published by the Congressional Budget Office of the United States, in April 2021, private spending on pharmaceutical research and development and the approval of new drugs has increased significantly from the past years. It also stated that, the number of newly approved drugs has also increased from the last years. Modern drug discovery uses libraries of purified proteins. The proteins used in the initial steps of drug discovery should be highly purified ones and structural features of proteins must be preserved because protein function is highly dependent on tertiary structure. Thus, protein purification is an essential steps for drug discovery and development. Therefore, such facts are anticipated to propel the demand of protein purification and isolation procedures, thereby postively impacting the market growth over the forecast period.

However, high cost of purification instruments and lack of skilled professionals are likely to impede the market growth over the forecast period.

Protein Purification & Isolation Market Trends

This section covers the major market trends shaping the Protein Purification & Isolation Market according to our research experts:

Ultrafiltration Segment is Expected to Witness Growth Over the Forecast Period

Ultrafiltration is the process of separating extremely small particles and dissolved molecules from liquids. The primary basis for separation is the size of the molecules, although the permeability of the filter can be affected by the chemical, molecular or electrostatic properties of the sample. To be separated by ultrafiltration, molecules must differ in size by at least an order of magnitude and have a molecular weight between 1 kDa and 1000 kDa. Ultrafiltration membranes can be used either to clean the filtrate or to collect the retentate. Ultrafiltration is typically used for the separation of proteins from buffer components for buffer exchange, concentration, or desalting.

The advantages of ultrafiltration and wide application of ultrafiltration for protein purification and isolation are the major drivers for the segment growth over the forecast period. For instance, according to the study titled, "Recent Advancements of UF-Based Separation for Selective Enrichment of Proteins and Bioactive Peptides—A Review" published in January 2021, proteins could be beneficial in their concentrated products or isolates, of which membrane filtration methods such as ultrafiltration include application in a wide range of protein sources. Furthermore, advantages of ultrafiltration technology such as, the high product throughput and ability to generate rapid results are also boosting the use of ultrafiltration. Moreover, traditional techniques such as chromatography require complex instrumentation support to run efficiently and yield low throughput of product at an extremely high cost owing to which ultrafiltration technique is becoming more popular as it overcome such disadvantages.

Therefore, due to the above mentioned factors considerable segment growth is anticipated over the forecast period.

Protein Purification and Isolation Market Trends

North America is Expected to Dominate the Protein Purification and Isolation Market Over the Forecast Period

North America is expected to dominate the protein purification and isolation market, over the forecast period. The growth is due to factors such as increasing research work and rising investments in R&D by the public and private sectors. For instance, as per the report published by Research America in January 2022, the estimated Medical and Health R&D Investment in the United States were USD 245,127 million in 2020, whereas in 2019 it was around USD 221,438 million. It also reported that the investment in R&D by industrial players has also increased from the previous years. In 2020, the investment by industry was USD 161,766 million whereas in 2019 it was around USD 148,205 million. Therefore, increased investment indicates that both public and private sectors are focusing on developing new and advanced products. Therefore, such a factor is anticipated to promote market growth in North America.

Key product launches, high concentration of market players or manufacturer's presence, and acquisition & partnerships among major players, and increased investments by biopharmaceutical companies in R&D in the United States are some of the factors driving the growth of protein purification and isolation market in the country. For instance, according to the report published by the Research America in January 2022, the biopharmaceutical companies invested around USD 122,204 million in 2020, wheras in 2019 the investment was around USD 110,932 million in R&D. Therefore, such fact is anticipated to drive the growth of the market in the country

Therefore, owing to the aforesaid factors the growth of the studied market is anticipated in the North America Region.

Protein Purification and Isolation Market Growth Rate

Protein Purification & Isolation Industry Overview

The protein purification ad isolation market is fragmented in nature due to the presence of several companies operating globally as well as regionally. The competitive landscape includes an analysis of a few international as well as local companies which hold the market shares and are well known including Thermo Fisher Scientific Inc., Merck KGaA, QIAGEN, Bio-Rad Laboratories, Inc., Agilent Technologies, Inc., Promega Corporation, and Danaher Corporation (Cytiva) among others.

Protein Purification & Isolation Market Leaders

  1. Thermo Fischer Scientific Inc.

  2. Merck KGaA

  3. QIAGEN

  4. Bio-Rad Laboratories, Inc.

  5. Promega Corporation

*Disclaimer: Major Players sorted in no particular order

Thermo Fischer Scientific Inc., Merck KGaA, QIAGEN, Bio-Rad Laboratories, Inc., Promega Corporation
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Protein Purification & Isolation Market News

  • In May 2021, Cytvia launched AKTA pure microsystem and fraction collector F9-T for AKTA pure 25 protein purification system. The product helps to increase the resolution in microscale protein purification.
  • In March 2021, Promega Corporation launched XpressAmp Direct Amplification Reagents that facilitate automation-friendly sample preparation without RNA extraction. With this innovation, laboratories testing for COVID-19 have a new tool that allows them to skip the potentially limiting RNA extraction step in the workflow and go directly to polymerase chain reaction (PCR) amplification.

Protein Purification & Isolation Market Report - Table of Contents

  1. 1. INTRODUCTION

    1. 1.1 Study Assumptions and Market Defination

    2. 1.2 Scope of the Study

  2. 2. RESEARCH METHODOLOGY

  3. 3. EXECUTIVE SUMMARY

  4. 4. MARKET DYNAMICS

    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Increasing Cases of Exocrine Pancreatic Insufficiency

      2. 4.2.2 Growing Need for More Accurate and Rapid Purification Kits

      3. 4.2.3 Increasing Drug Discovery and Development and Technological Advancements

    3. 4.3 Market Restraints

      1. 4.3.1 High cost of Purification Instruments and Lack of Skilled Professionals

    4. 4.4 Porter's Five Force Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION

    1. 5.1 By Product

      1. 5.1.1 Instruments

      2. 5.1.2 Consumables

        1. 5.1.2.1 Kits

        2. 5.1.2.2 Reagents

        3. 5.1.2.3 Columns

        4. 5.1.2.4 Others

    2. 5.2 By Technology

      1. 5.2.1 Precipitaion

      2. 5.2.2 Ultrafiltration

      3. 5.2.3 Chromatography

        1. 5.2.3.1 Ion Exchange Chromatography

        2. 5.2.3.2 Size Exclusion Chromatography

        3. 5.2.3.3 Reversed Phase Chromatography

        4. 5.2.3.4 Others

      4. 5.2.4 Electrophoresis

        1. 5.2.4.1 Gel electrophoresis

        2. 5.2.4.2 Capillary electrophoresis

        3. 5.2.4.3 Isoelectric focusing

      5. 5.2.5 Western Blotting

      6. 5.2.6 Others

    3. 5.3 By End User

      1. 5.3.1 Academic and Research Institutes

      2. 5.3.2 Pharmaceutical and Biotechnological Companies

      3. 5.3.3 Contract Research Organizations (CROs)

      4. 5.3.4 Hospitals

    4. 5.4 Geography

      1. 5.4.1 North America

        1. 5.4.1.1 United States

        2. 5.4.1.2 Canada

        3. 5.4.1.3 Mexico

      2. 5.4.2 Europe

        1. 5.4.2.1 Germany

        2. 5.4.2.2 United Kingdom

        3. 5.4.2.3 France

        4. 5.4.2.4 Italy

        5. 5.4.2.5 Spain

        6. 5.4.2.6 Rest of Europe

      3. 5.4.3 Asia-Pacific

        1. 5.4.3.1 China

        2. 5.4.3.2 Japan

        3. 5.4.3.3 India

        4. 5.4.3.4 Australia

        5. 5.4.3.5 South Korea

        6. 5.4.3.6 Rest of Asia-Pacific

      4. 5.4.4 Middle-East and Africa

        1. 5.4.4.1 GCC

        2. 5.4.4.2 South Africa

        3. 5.4.4.3 Rest of Middle-East and Africa

      5. 5.4.5 South America

        1. 5.4.5.1 Brazil

        2. 5.4.5.2 Argentina

        3. 5.4.5.3 Rest of South America

  6. 6. COMPETITIVE LANDSCAPE

    1. 6.1 Company Profiles

      1. 6.1.1 Thermo Fisher Scientific Inc.

      2. 6.1.2 Merck KGaA

      3. 6.1.3 QIAGEN

      4. 6.1.4 Bio-Rad Laboratories, Inc.

      5. 6.1.5 Agilent Technologies, Inc.

      6. 6.1.6 Promega Corporation

      7. 6.1.7 Danaher Corporation (Cytiva)

      8. 6.1.8 Norgen Biotek Corp.

      9. 6.1.9 Abcam plc

      10. 6.1.10 Purolite

    2. *List Not Exhaustive
  7. 7. MARKET OPPORTUNITIES AND FUTURE TRENDS

**Subject to Availability
**Competitive Landscape covers- Business Overview, Financials, Products and Strategies and Recent Developments
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Protein Purification & Isolation Industry Segmentation

As per the scope of the report, protein purification can be defined as a series of steps that are performed to obtain and study the desired protein from a complex mixture. Protein purification is vital for characterizing the function, structure, and interactions of the required protein. The protein isolation aims to safely and efficiently separate the required protein from a mixture. Isolation of proteins is carried out from samples of mammals, insects, plants, yeasts, or bacteria. The protein purification and isolation market is segmented by Product (Instruments and Consumables), by Technology (Precipitation, Ultrafiltration, Chromatography, Electrophoresis, and Western Blotting), by End User (Academic and Research Institutes, Pharmaceutical and Biotechnological Companies, Contract Research Organizations (CROs), and Hospitals) and Geography (North America, Europe, Asia-Pacific, Middle East, and Africa, and South America). The market report also covers the estimated market sizes and trends for 17 different countries across major regions, globally. The report offers the value (in USD million) for the above segments.

By Product
Instruments
Consumables
Kits
Reagents
Columns
Others
By Technology
Precipitaion
Ultrafiltration
Chromatography
Ion Exchange Chromatography
Size Exclusion Chromatography
Reversed Phase Chromatography
Others
Electrophoresis
Gel electrophoresis
Capillary electrophoresis
Isoelectric focusing
Western Blotting
Others
By End User
Academic and Research Institutes
Pharmaceutical and Biotechnological Companies
Contract Research Organizations (CROs)
Hospitals
Geography
North America
United States
Canada
Mexico
Europe
Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific
China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle-East and Africa
GCC
South Africa
Rest of Middle-East and Africa
South America
Brazil
Argentina
Rest of South America
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Protein Purification & Isolation Market Research FAQs

The Global Protein Purification and Isolation Market is projected to register a CAGR of 10.9% during the forecast period (2023-2028).

Thermo Fischer Scientific Inc., Merck KGaA, QIAGEN, Bio-Rad Laboratories, Inc. and Promega Corporation are the major companies operating in the Global Protein Purification and Isolation Market.

Asia-Pacific is estimated to grow at the highest CAGR over the forecast period (2023-2028).

In 2023, the North America accounts for the largest market share in the Global Protein Purification and Isolation Market.

Global Protein Purification and Isolation Industry Report

Statistics for the 2023 Global Protein Purification and Isolation market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Global Protein Purification and Isolation analysis includes a market forecast outlook to 2028 and historical overview. Get a sample of this industry analysis as a free report PDF download.

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