Market Trends of Global Androgen Deprivation Therapy Industry
This section covers the major market trends shaping the Androgen Deprivation Therapy Market according to our research experts:
Antiandrogen Sub Segment Within Drug Class Segment is Expected to Account Large Market Share Over the Forecast Period
Anti-androgens are drugs that connect to the androgen receptors, inhibiting the androgens from causing tumor growth. Anti-androgens are also sometimes called androgen receptor antagonists. Antiandrogens drug include Flutamide (Eulexin), Bicalutamide (Casodex), Nilutamide (Nilandron), Enzalutamide (Xtandi), apalutamide (Erleada) and darolutamide (Nubeqa).
Factors such as rising incidences of prostate cancer globally, product approvals, growing geriatric population, increasing research and development activities, and strategies adopted by key market players such as partnerships will effectively contribute to the market growth.
The growing research activities in the segment are expected to fuel the market growth. For instance, In December 2021, Bayer published the results from the Phase III ARASENS trial, which investigated the use of the oral androgen receptor inhibitor (ARi) Nubeqa (darolutamide), an anti-androgen, in metastatic hormone-sensitive prostate cancer (mHSPC). The company stated that darolutamide, in combination with docetaxel and androgen deprivation therapy (ADT), significantly increased overall survival compared to docetaxel and ADT.
Additionally, in September 2021, Astellas Pharma Inc. and Pfizer Inc. stated that XTANDI (enzalutamide), an anti-androgen, improved overall survival in men with metastatic hormone-sensitive prostate cancer in which is proved through the ARCHES study. Such studies highlight the efficacies of anti-androgens in treating prostate cancer in terms of increased overall survival rate, which boosts the application of anti-androgen, hence driving the market.
Furthermore, In February 2021, Bayer, in partnership with Orion Corporation, expanded the global clinical development program for the oral androgen receptor inhibitor (ARi) Nubeqa (darolutamide) in the area of prostate cancer. The company initiated a Phase III study ARANOTE which will evaluate the compound in addition to androgen deprivation therapy (ADT) versus placebo plus ADT in men with metastatic hormone-sensitive prostate cancer (mHSPC). Such strategies will allow companies to leverage others’ strengths and develop an advanced product in the area of prostate cancer, thereby leading to lucrative growth of the market.
Thus, due to the above-mentioned factors, the studied segment is expected to contribute to the significant growth of the market.
North America is Expected to Hold a Significant Share in the Market and Expected to do Same in the Forecast Period
The primary driving factors for the growth of the North American androgen deprivation therapy (ADT) market are the rising prevalence of prostate cancer, the growing geriatric population, product launches, and several initiatives and investments made by key market players.
The United States within North America is expected to hold a significant share of the studied market during the study period. Prostate cancer is the most common cancer in American men. The American Cancer Society estimates that in the United States, in 2022, about 268,490 new cases of prostate cancer and approximately 34,500 deaths from prostate cancer will be reported. Thus, a huge burden of prostate cancer n the country increases the demand for its therapeutics, which can suppress the amount of testosterone formed, thereby contributing to the market growth.
The above-mentioned source also suggests that prostate cancer is more likely to develop in older men. About 6 cases in 10 are diagnosed in men who are 65 or older, and it is rare in men under 40. The average age of men at diagnosis is about 66. Thereby, the growing elderly population in the region will also increase the incidence rate of prostate cancer, hence propelling the market.
The rising research and development studies that are proving the efficacies of androgen receptor inhibitors in treating pancreatic cancer will contribute to the market growth. For instance, in February 2021, the Janssen Pharmaceutical Companies of Johnson & Johnson released results from the final analysis of the Phase 3 TITAN study stating that ERLEADA, in combination with ADT, provided a statistically significant improvement in overall survival rate with a 35% reduction in risk of death versus ADT alone. Such technological improvement in treatment procedures is expected to drive market growth.
In January 2021, the United States Food and Drug Administration approved Relugolix (Orgovyx) for treating adults with prostate cancer as it is more effective at reducing testosterone levels in men with advanced prostate cancer than another commonly used treatment, leuprolide (Lupron).
Therefore, due to the above-mentioned factors, the studied market is expected to lead to lucrative growth of the market in North America.
